Indican Inhibitor

MBS5756249 is an inhibitor targeting Indican. Indican is a natural protective compound that is used to protect the liver.

Prokopienko AJ, Nolin TD. Microbiota-derived uremic retention solutes: perpetrators of altered nonrenal drug clearance in kidney disease. Expert Rev Clin Pharmacol. 2018 Jan;11(1):71-82. doi: 10.1080/17512433.2018.1378095. Epub 2017 Sep 20. Review. PubMed PMID: 28905671.
KamiA, ski T, Michalowska M, Pawlak D. Aryl hydrocarbon receptor (AhR) and its endogenous agonist - indoxyl sulfate in chronic kidney disease. Postepy Hig Med Dosw (Online). 2017 Jul 30;71(0):624-632. Review. PubMed PMID: 28791957.
Gao H, Liu S. Role of uremic toxin indoxyl sulfate in the progression of cardiovascular disease. Life Sci. 2017 Sep 15;185:23-29. doi: 10.1016/j.lfs.2017.07.027. Epub 2017 Jul 25. Review. PubMed PMID: 28754616.
Wu CC, Hung SC, Kuo KL, Tarng DC. Impact of Indoxyl Sulfate on Progenitor Cell-Related Neovascularization of Peripheral Arterial Disease and Post-Angioplasty Thrombosis of Dialysis Vascular Access. Toxins (Basel). 2017 Jan 7;9(1). pii: E25. doi: 10.3390/toxins9010025. Review. PubMed PMID: 28067862; PubMed Central PMCID: PMC5308257.

Small volumes of Indican, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.