GSNO Inhibitor

GSNO is an endogenous transnitrosation donor involved in S-nitrosation of a variety of cellular proteins.

Tsikas D, Schwedhelm KS, Surdacki A, Giustarini D, Rossi R, Kukoc-Modun L, Kedia G, aœckert S. S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET)-Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H(2)S and GSH suppliers and as antioxidants: Results and overview. J Pharm Anal. 2018 Feb;8(1):1-9. doi: 10.1016/j.jpha.2017.12.003. Epub 2017 Dec 13. Review. PubMed PMID: 29568662; PubMed Central PMCID: PMC5859134.
Cassia R, Nocioni M, Correa-Aragunde N, Lamattina L. Climate Change and the Impact of Greenhouse Gasses: CO(2) and NO, Friends and Foes of Plant Oxidative Stress. Front Plant Sci. 2018 Mar 1;9:273. doi: 10.3389/fpls.2018.00273. eCollection 2018. Review. PubMed PMID: 29545820; PubMed Central PMCID: PMC5837998.
Khan M, Khan H, Singh I, Singh AK. Hypoxia inducible factor-1 alpha stabilization for regenerative therapy in traumatic brain injury. Neural Regen Res. 2017 May;12(5):696-701. doi: 10.4103/1673-5374.206632. Review. PubMed PMID: 28616019; PubMed Central PMCID: PMC5461600.
Barnett SD, Buxton ILO. The role of S-nitrosoglutathione reductase (GSNOR) in human disease and therapy. Crit Rev Biochem Mol Biol. 2017 Jun;52(3):340-354. doi: 10.1080/10409238.2017.1304353. Epub 2017 Apr 10. Review. PubMed PMID: 28393572; PubMed Central PMCID: PMC5597050.

Small volumes of GSNO, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756271 is an inhibitor targeting GSNO.