Clemastine Inhibitor

Clemastine has been found to rescue impaired myelination and reverse social avoidance behavior in mice.

Turski CA, Turski GN, Chen B, Wang H, Heidari M, Li L, Noguchi KK, Westmark C, Duncan I, Ikonomidou C. Clemastine effects in rat models of a myelination disorder. Pediatr Res. 2018 May 2. doi: 10.1038/pr.2018.45. [Epub ahead of print] PubMed PMID: 29584714.
Domagala A, Szepietowski J, Reich A. Antihistamines in the treatment,of pruritus in psoriasis. Postepy Dermatol Alergol. 2017 Oct;34(5):457-463. doi: 10.5114/ada.2017.71112. Epub 2017 Oct 31. PubMed PMID: 29507561; PubMed Central PMCID: PMC5831281.
Magno Pereira V, Andrade C, Figueira R, Faria G, Jasmins L. Infliximab-Induced Lupus: A Case Report. GE Port J Gastroenterol. 2017 Mar;24(2):84-88. doi: 10.1159/000450877. Epub 2016 Nov 19. PubMed PMID: 29255743; PubMed Central PMCID: PMC5729968.
Cree BAC, Niu J, Hoi KK, Zhao C, Caganap SD, Henry RG, Dao DQ, Zollinger DR, Mei F, Shen YA, Franklin RJM, Ullian EM, Xiao L, Chan JR, Fancy SPJ. Clemastine rescues myelination defects and promotes functional recovery in hypoxic brain injury. Brain. 2018 Jan 1;141(1):85-98. doi: 10.1093/brain/awx312. PubMed PMID: 29244098.

Small volumes of Clemastine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756287 is an inhibitor targeting Clemastine.