Bucladesine Inhibitor

Bucladesine is a cyclic nucleotide derivative which mimics the action of endogenous cAMP and is capable of permeating the cell membrane. Bucladesine is a phosphodiesterase inhibitor. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions.

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Aghsami M, Sharifzadeh M, Sepand MR, Yazdankhah M, Seyednejad SA, Pourahmad J. A cAMP analog attenuates beta-amyloid (1-42)-induced mitochondrial dysfunction and spatial learning and memory deficits. Brain Res Bull. 2018 Mar 29;140:34-42. doi: 10.1016/j. Brainresbull.2018.03.016. [Epub ahead of print] PubMed PMID: 29605485.
Rodrigues AL, Brescia M, Koschinski A, Moreira TH, Cameron RT, Baillie G, Beira£o PSL, Zaccolo M, Cruz JS. Increase in Ca(2+) current by sustained cAMP levels enhances proliferation rate in GH3 cells. Life Sci. 2018 Jan 1;192:144-150. doi: 10.1016/j.lfs.2017.11.040. Epub 2017 Nov 26. PubMed PMID: 29183797.
Tamura K, Ishikawa G, Yoshie M, Ohneda W, Nakai A, Takeshita T, Tachikawa E. Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1beta secretion in human trophoblasts. J Pharmacol Sci. 2017 Oct;135(2):89-95. doi: 10.1016/j.jphs.2017.09.032. Epub 2017 Oct 6. PubMed PMID: 29056256.

Small volumes of Bucladesine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756385 is an inhibitor targeting Bucladesine.