Fosinoprilat Inhibitor

Fosinoprilat, an active phosphinic acid metabolite of prodrug fosenopril, is activated by esterases in vivo. Fosinoprilat binds zinc with phosphinic acid group.

Xue K, Li G, Sun X, Hu Y, Hu L, Huang J, Si L. Simultaneous quantification of fosinopril and its active metabolite fosinoprilat in rat plasma by UFLC-MS/MS: Application of formic acid in the stabilization of an ester-containing drug. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 May 15;990:141-9. doi: 10.1016/j.jchromb.2015.03.028. Epub 2015 Apr 3. PubMed PMID: 25875586.
Yang S, Li R, Qu X, Tang L, Ge G, Fang W, Qiao Z, Ma J, Hou Y, Liu H. Fosinoprilat alleviates lipopolysaccharide (LPS)-induced inflammation by inhibiting TLR4/NF-kappaB signaling in monocytes. Cell Immunol. 2013 Jul-Aug;284(1-2):182-6. doi: 10.1016/j.cellimm.2013.06.009. Epub 2013 Jun 28. PubMed PMID: 24036412.
Uutela P, Monto M, Iso-Mustajarvi I, Madetoja M, Yliperttula M, Ketola RA. Identification of metabolites of fosinopril produced by human and rat liver microsomes with liquid chromatography-mass spectrometry. Eur J Pharm Sci. 2014 Mar 12;53:86-94. doi: 10.1016/j.ejps.2013.12.009. Epub 2013 Dec 21. PubMed PMID: 24365260.
Hu OY, Ding PY, Huang CS, Hwang GM, Chu KM. Pharmacokinetics of fosinoprilat in Chinese and whites after intravenous administration. J Clin Pharmacol. 1997 Sep;37(9):834-40. PubMed PMID: 9549638.

Small volumes of Fosinoprilat, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756453 is an inhibitor targeting Fosinoprilat.