Heliotrine Inhibitor

MBS5756454 is an inhibitor targeting Heliotrine. Heliotrine leads to apoptosis of the human hepatoma cell line HepaRG.

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He X, Xia Q, Woodling K, Lin G, Fu PP. Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides. J Food Drug Anal. 2017 Oct;25(4):984-991. doi: 10.1016/j.jfda.2017.09.001. Epub 2017 Sep 19. PubMed PMID: 28987376.
Huybrechts B, Callebaut A. Pyrrolizidine alkaloids in food and feed on the Belgian market. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(11):1939-51. doi: 10.1080/19440049.2015.1086821. Epub 2015 Oct 15. PubMed PMID: 26373269.
Luckert C, Hessel S, Lenze D, Lampen A. Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis. Toxicol In Vitro. 2015 Oct;29(7):1669-82. doi: 10.1016/j. Tiv.2015.06.021. Epub 2015 Jun 20. PubMed PMID: 26100227.

Small volumes of Heliotrine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.