Unoprostone isopropyl Inhibitor

Unoprostone isopropyl, a prostanoid and synthetic docosanoid, is approved for the treatment,of ocular hypertension and open-angle glaucoma.

Akiyama M, Ikeda Y, Yoshida N, Notomi S, Murakami Y, Hisatomi T, Enaida H, Ishibashi T. Therapeutic efficacy of topical unoprostone isopropyl in retinitis pigmentosa. Acta Ophthalmol. 2014 May;92(3):e229-34. PubMed PMID: 24868583.
Tanano I, Nagaoka T, Ono S, Omae T, Otani S, Yoshida A. Vasodilatory mechanisms of unoprostone isopropyl in isolated porcine retinal arterioles. Mol Vis. 2015 Jun 12;21:699-705. eCollection 2015. PubMed PMID: 26120274; PubMed Central PMCID: PMC4463970.
Harms NV, Toris CB. Current status of unoprostone for the management of glaucoma and the future of its use in the treatment,of retinal disease. Expert Opin Pharmacother. 2013 Jan;14(1):105-13. doi: 10.1517/14656566.2013.748038. Epub 2012 Nov 30. Review. PubMed PMID: 23199345.
Cuppoletti J, Malinowska DH, Tewari KP, Chakrabarti J, Ueno R. Unoprostone isopropyl and metabolite M1 activate BK channels and prevent ET-1-induced [Ca^2+]i increases in human trabecular meshwork and smooth muscle. Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5178-89. doi: 10.1167/iovs.11-9046. PubMed PMID: 22786902.

Small volumes of Unoprostone isopropyl, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756495 is an inhibitor targeting Unoprostone isopropyl.