Temocaprilat Inhibitor

Temocaprilat, the diacid of temocapril, is an angiotensin-converting enzyme inhibitor.

Puchler K, Sierakowski B, Roots I. Single dose and steady state pharmacokinetics of temocapril and temocaprilat in young and elderly hypertensive patients. Br J Clin Pharmacol. 1998 Oct;46(4):363-7. PubMed PMID: 9803985; PubMed Central PMCID: PMC1874161.
Yasunari K, Maeda K, Watanabe T, Nakamura M, Asada A, Yoshikawa J. Converting enzyme inhibitor temocaprilat prevents high glucose-mediated suppression of human aortic endothelial cell proliferation. J Cardiovasc Pharmacol. 2003 Dec;42 Suppl 1:S55-60. PubMed PMID: 14871030.
Puchler K, Eckl KM, Fritsche L, Renneisen K, Neumayer HH, Sierakowski B, Lavrijssen AT, Thomsen T, Roots I. Pharmacokinetics of temocapril and temocaprilat after 14 once daily oral doses of temocapril in hypertensive patients with varying degrees of renal impairment. Br J Clin Pharmacol. 1997 Dec;44(6):531-6. PubMed PMID: 9431827; PubMed Central PMCID: PMC2042893.
Ishizuka H, Konno K, Naganuma H, Nishimura K, Kouzuki H, Suzuki H, Stieger B, Meier PJ, Sugiyama Y. Transport of temocaprilat into rat hepatocytes: role of organic anion transporting polypeptide. J Pharmacol Exp Ther. 1998 Oct;287(1):37-42. PubMed PMID: 9765319.

Small volumes of Temocaprilat, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756512 is an inhibitor targeting Temocaprilat.