Lilial Inhibitor

Lilial is a high-tonnage perfumery ingredient with an odour of lily-of-the-valley. It is a CMR2 material.

Schroeder M, Mathys M, Ehrensperger N, Buchel M. gamma-Unsaturated aldehydes as potential Lilial replacers. Chem Biodivers. 2014 Oct;11(10):1651-73. doi: 10.1002/cbdv.201400072. PubMed PMID: 25329790.
Usta J, Hachem Y, El-Rifai O, Bou-Moughlabey Y, Echtay K, Griffiths D, Nakkash-Chmaisse H, Makki RF. Fragrance chemicals lyral and lilial decrease viability of HaCat cells' by increasing free radical production and lowering intracellular ATP level: protection by antioxidants. Toxicol In Vitro. 2013 Feb;27(1):339-48. doi: 10.1016/j. Tiv.2012.08.020. Epub 2012 Aug 24. PubMed PMID: 22940465.
Esmaeili A, Afshari S, Esmaeili D. Formation of harmful compounds in biotransformation of lilial by microorganisms isolated from human skin. Pharm Biol. 2015;53(12):1768-73. doi: 10.3109/13880209.2015.1005755. Epub 2015 Apr 9. PubMed PMID: 25856710.
Stueckler C, Mueller NJ, Winkler CK, Glueck SM, Gruber K, Steinkellner G, Faber K. Bioreduction of alpha-methylcinnamaldehyde derivatives: chemo-enzymatic asymmetric synthesis of Lilial and Helional. Dalton Trans. 2010 Sep 28;39(36):8472-6. doi: 10.1039/c002971h. Epub 2010 May 11. PubMed PMID: 20461254.

Small volumes of Lilial, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756528 is an inhibitor targeting Lilial.