Sivelestat Sodium Inhibitor

MBS5756531 is an inhibitor targeting Sivelestat Sodium. Sivelestat Sodium could inhibit human neutrophil elastase.

Okamoto H, Onodera K, Kamba R, Taniyama Y, Sakurai T, Heishi T, Teshima J, Hikage M, Sato C, Maruyama S, Onodera Y, Ishida H, Kamei T. treatment,of spontaneous esophageal rupture (Boerhaave syndrome) using thoracoscopic surgery and sivelestat sodium hydrate. J Thorac Dis. 2018 Apr;10(4):2206-2212. doi: 10.21037/jtd.2018.03.136. PubMed PMID: 29850124; PubMed Central PMCID: PMC5949456.
Pu S, Wang D, Liu D, Zhao Y, Qi D, He J, Zhou G. Effect of sivelestat sodium in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of randomized controlled trials. BMC Pulm Med. 2017 Nov 21;17(1):148. doi: 10.1186/s12890-017-0498-z. PubMed PMID: 29162066; PubMed Central PMCID: PMC5699178.
Ogawa R, Mori R, Iida K, Uchida Y, Oshiro M, Kageyama M, Kato Y, Tanaka T, Nakata Y, Nishimura Y, Hokuto I, Bonno M, Matsumoto N, Ito M, Takahashi N, Namba F. Effects of the early administration of sivelestat sodium on bronchopulmonary dysplasia in infants: A retrospective cohort study. Early Hum Dev. 2017 Dec;115:71-76. doi: 10.1016/j.earlhumdev.2017.09.016. Epub 2017 Sep 23. PubMed PMID: 28950234.
Yu X, Zhao L, Yu Z, Yu C, Bi J, Sun B, Cong H. Sivelestat sodium hydrate improves post-traumatic knee osteoarthritis through nuclear factor-kappaB in a rat model. Exp Ther Med. 2017 Aug;14(2):1531-1537. doi: 10.3892/etm.2017.4684. Epub 2017 Jun 27. PubMed PMID: 28810618; PubMed Central PMCID: PMC5526152.

Small volumes of Sivelestat Sodium, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.