Loratadine specified impurity F Inhibitor

MBS5756554 is an inhibitor targeting Loratadine specified impurity F. Loratadine specified impurity F is a fluorinated analog of Loratadine.

Patel JZ, Ahenkorah S, Vaara M, Staszewski M, Adams Y, Laitinen T, Navia-Paldanius D, Parkkari T, Savinainen JR, WalczyA, ski K, Laitinen JT, Nevalainen TJ. Loratadine analogues as MAGL inhibitors. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1436-42. doi: 10.1016/j. Bmcl.2015.02.037. Epub 2015 Feb 24. PubMed PMID: 25752982.
Baumann-Birkbeck L, Grant GD, Anoopkumar-Dukie S, Kavanagh JJ. Drowsiness and motor responses to consecutive daily doses of promethazine and loratadine. Clin Neurophysiol. 2014 Dec;125(12):2390-6. doi: 10.1016/j.clinph.2014.03.026. Epub 2014 Apr 12. PubMed PMID: 24791618.
Li W, Doherty J, Moench P, Flarakos J, Tse FL. LC-MS/MS bioanalysis of loratadine (Claritin) in dried blood spot (DBS) samples collected by subjects in a clinical research study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Mar 1;983-984:117-24. doi: 10.1016/j.jchromb.2014.12.033. Epub 2015 Jan 13. PubMed PMID: 25645810.
Li H, Tan Y, Yang L, Gao L, Wang T, Yang X, Quan D. Dissolution evaluation in vitro and bioavailability in vivo of self-microemulsifying drug delivery systems for pH-sensitive drug loratadine. J Microencapsul. 2015;32(2):175-80. doi: 10.3109/02652048.2014.985340. Epub 2014 Nov 21. PubMed PMID: 25413271.

Small volumes of Loratadine specified impurity F, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.