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Deacylketoconazole Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5756617

Deacylketoconazole is a Ketoconazole derivative. Ketoconazole is an antifungal drug used primarily for the treatment,of fungal infections. More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Deacylketoconazole, Inhibitor
Full Product Name
Deacylketoconazole
Product Synonym Names
Deacyl ketoconazole; Deacyl ketoconazole
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
489.4
Solubility
DMSO: Soluble
(<1mg/ refers to the product slightly soluble or insoluble)
Formula
C24H26Cl2N4O3
SMILES
ClC1=CC=C([C@]2(CN3C=CN=C3)OC[C@@H](COC4=CC=C(N5CCNCC5)C=C4)O2)C(Cl)=C1
CAS Number
67914-61-8

Product References and Citations for Deacylketoconazole, inhibitor

Fukami T, Iida A, Konishi K, Nakajima M. Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity. Biochem Pharmacol. 2016 Sep 15;116:153-61. doi: 10.1016/j. Bcp.2016.07.007. Epub 2016 Jul 12. PubMed PMID: 27422753.
Wewering F, Jouy F, Wissenbach DK, Gebauer S, Bluher M, Gebhardt R, Pirow R, von Bergen M, Kalkhof S, Luch A, Zellmer S. Characterization of chemical-induced sterile inflammation in vitro: application of the model compound ketoconazole in a human hepatic co-culture system. Arch Toxicol. 2017 Feb;91(2):799-810. doi: 10.1007/s00204-016-1686-y. Epub 2016 Mar 10. PubMed PMID: 26965496.
Rodriguez RJ, Miranda CL. Isoform specificity of N-deacetyl ketoconazole by human and rabbit flavin-containing monooxygenases. Drug Metab Dispos. 2000 Sep;28(9):1083-6. PubMed PMID: 10950853.
Rodriguez RJ, Proteau PJ, Marquez BL, Hetherington CL, Buckholz CJ, O'Connell KL. Flavin-containing monooxygenase-mediated metabolism of N-deacetyl ketoconazole by rat hepatic microsomes. Drug Metab Dispos. 1999 Aug;27(8):880-6. PubMed PMID: 10421614.

Other Notes

Small volumes of Deacylketoconazole, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Deacylketoconazole purchase

MBS5756617 is an inhibitor targeting Deacylketoconazole.
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