Adenanthin Inhibitor

Adenanthin, a natural inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells.

Siernicka M, Winiarska M, Bajor M, Firczuk M, Muchowicz A, Bobrowicz M, Fauriat C, Golab J, Olive D, Zagozdzon R. Adenanthin, a new inhibitor of thiol-dependent antioxidant enzymes, impairs the effector functions of human natural killer cells. Immunology. 2015 Sep;146(1):173-83. doi: 10.1111/imm.12494. Epub 2015 Jul 8. PubMed PMID: 26094816; PubMed Central PMCID: PMC4552512.
Soethoudt M, Peskin AV, Dickerhof N, Paton LN, Pace PE, Winterbourn CC. Interaction of adenanthin with glutathione and thiol enzymes: selectivity for thioredoxin reductase and inhibition of peroxiredoxin recycling. Free Radic Biol Med. 2014 Dec;77:331-9. doi: 10.1016/j.freeradbiomed.2014.09.025. Epub 2014 Oct 5. PubMed PMID: 25289458.
Hou JK, Huang Y, He W, Yan ZW, Fan L, Liu MH, Xiao WL, Sun HD, Chen GQ. Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells. Cell Death Dis. 2014 Sep 4;5:e1400. doi: 10.1038/cddis.2014.345. PubMed PMID: 25188510; PubMed Central PMCID: PMC4540188.
Muchowicz A, Firczuk M, Chlebowska J, Nowis D, Stachura J, Barankiewicz J, Trzeciecka A, Klossowski S, Ostaszewski R, Zagozdzon R, Pu JX, Sun HD, Golab J. Adenanthin targets proteins involved in the regulation of disulphide bonds. Biochem Pharmacol. 2014 May 15;89(2):210-6. doi: 10.1016/j. Bcp.2014.02.022. Epub 2014 Mar 11. PubMed PMID: 24630929.

Small volumes of Adenanthin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756619 is an inhibitor targeting Adenanthin.