Apovincamine Inhibitor

Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.

Solovyeva EY, Karneev AN, Chekanov AV, Baranova OA, Choi IV. [Complex application 2-ethyl-6-methyl-3-hydroxypyridine-succinate and vinpocetine in cerebrovascular disorder.]. Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(5):103-108. doi: 10.17116/jnevro201711751103-108. Review. Russian. PubMed PMID: 28638040.
Feher G, Koltai K, Kesmarky G, Horvath B, Toth K, Komoly S, Szapary L. Effect of parenteral or oral vinpocetine on the hemorheological parameters of patients with chronic cerebrovascular diseases. Phytomedicine. 2009 Mar;16(2-3):111-7. doi: 10.1016/j.phymed.2008.10.014. Epub 2009 Jan 8. PubMed PMID: 19135345.
Szatmari SZ, Whitehouse PJ. Vinpocetine for cognitive impairment and dementia. Cochrane Database Syst Rev. 2003;(1):CD003119. Review. PubMed PMID: 12535455.
Jucker M, Battig K, Meier-Ruge W. Effects of aging and vincamine derivatives on pericapillary microenvironment: stereological characterization of the cerebral capillary network. Neurobiol Aging. 1990 Jan-Feb;11(1):39-46. Erratum in: Neurobiol Aging 1990 Nov-Dec;11(6):675. PubMed PMID: 2325815.

Small volumes of Apovincamine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756622 is an inhibitor targeting Apovincamine.