AICAR Inhibitor

AICAR, a purine precursor with antineoplastic activity, is important in the treatment,of metabolic diseases such as type 2 diabetes as well as a possible treatment,of various cancer types.

Chung EJ, Efstathiou NE, Konstantinou EK, Maidana DE, Miller JW, Young LH, Vavvas DG. AICAR suppresses TNF-alpha-induced complement factor B in RPE cells. Sci Rep. 2017 Dec 15;7(1):17651. doi: 10.1038/s41598-017-17744-w. PubMed PMID: 29247196; PubMed Central PMCID: PMC5732305.
Verma P, Kar B, Varshney R, Roy P, Sharma AK. Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) from Staphylococcus lugdunensis. FEBS J. 2017 Dec;284(24):4233-4261. doi: 10.1111/febs.14303. Epub 2017 Nov 13. PubMed PMID: 29063699.
Huang Y, Ratz PH, Miner AS, Locke VA, Chen G, Chen Y, Barbee RW. AICAR Administration Attenuates Hemorrhagic Hyperglycemia and Lowers Oxygen Debt in Anesthetized Male Rabbits. Front Physiol. 2017 Sep 13;8:692. doi: 10.3389/fphys.2017.00692. eCollection 2017. PubMed PMID: 28955248; PubMed Central PMCID: PMC5601404.
Nie J, Liu A, Tan Q, Zhao K, Hu K, Li Y, Yan B, Zhou L. AICAR activates ER stress-dependent apoptosis in gallbladder cancer cells. Biochem Biophys Res Commun. 2017 Jan 8;482(2):246-252. doi: 10.1016/j. Bbrc.2016.11.050. Epub 2016 Nov 12. PubMed PMID: 27847321.

Small volumes of AICAR, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756658 is an inhibitor targeting AICAR.