Dihydrolipoic acid Inhibitor

Dihydrolipoic acid, a dithiol-containing carboxylic acid, acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including peroxynitirite, hydroxyl radicals, hydrogen peroxide, and hypochlorite, at concentrations ranging from 0.01-0.5 mM.

Olah Z, Vogg ATJ, Kremmer T, SzA+/-cs Z, Varga Z, Doczi R. Optimization of the reduction of (74)As(V) to (74)As(III) and of the labelling of dithiol dihydrolipoic acid. Appl Radiat Isot. 2019 Jul;149:75-82. doi: 10.1016/j. Apradiso.2019.04.004. Epub 2019 Apr 15. PubMed PMID: 31029937.
Ren SH, Liu SG, Ling Y, Li NB, Luo HQ. Facile method for iodide ion detection via the fluorescence decrease of dihydrolipoic acid/beta-cyclodextrin protected Ag nanoclusters. Spectrochim Acta A Mol Biomol Spectrosc. 2019 Apr 5;212:199-205. doi: 10.1016/j.saa.2019.01.009. Epub 2019 Jan 4. PubMed PMID: 30639913.
Micillo R, Sires-Campos J, Garcia-Borron JC, Panzella L, Napolitano A, Olivares C. Conjugation with Dihydrolipoic Acid Imparts Caffeic Acid Ester Potent Inhibitory Effect on Dopa Oxidase Activity of Human Tyrosinase. Int J Mol Sci. 2018 Jul 24;19(8). pii: E2156. doi: 10.3390/ijms19082156. PubMed PMID: 30042336; PubMed Central PMCID: PMC6121902.
Zhou K, Enkhjargal B, Xie Z, Sun C, Wu L, Malaguit J, Chen S, Tang J, Zhang J, Zhang JH. Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat. Stroke. 2018 Jan;49(1):175-183. doi: 10.1161/STROKEAHA.117.018593. PubMed PMID: 29273596; PubMed Central PMCID: PMC5744882.

Small volumes of Dihydrolipoic acid, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756669 is an inhibitor targeting Dihydrolipoic acid.