Methylnaltrexone bromide Inhibitor

Methylnaltrexone, used in form of methylnaltrexone bromide, is one of the newer agents of peripherally-acting u-opioid antagonists. Methylnaltrexone acts to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals.

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Grover M, Camilleri M. treatment,with Methylnaltrexone and IVIG for Paraneoplastic Gastrointestinal Dysmotility. Gastroenterol Hepatol (N Y). 2013 Jan;9(1):51-3. Review. PubMed PMID: 24707236; PubMed Central PMCID: PMC3975980.
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Small volumes of Methylnaltrexone bromide, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756738 is an inhibitor targeting Methylnaltrexone bromide.