MK-212 Inhibitor

Name: MK-212 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5756754
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5756754

MK-212 is a 5HT2C-receptor agonist. Intraperitoneal injection of MK-212 in 0.5 and 1.0mg/kg increased the blood level of corticosterone in mice and reduced their motor activity. In 0.1 and 0.2mg/kg, the agonist reduced anxiety with no effect on motor activity. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MK-212, Inhibitor

Full Product Name

MK-212

Product Gene Name

MK-212, inhibitor

Product Synonym Names

MK 212; MK212; MK212

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

198.65

Solubility

Water: Insoluble
DMSO: Soluble
(<1mg/ refers to the product slightly soluble or insoluble)

Formula

C8H11ClN4

SMILES

ClC1=NC(N2CCNCC2)=CN=C1

CAS Number

64022-27-1

Product References and Citations for MK-212, inhibitor

Kozhevnikova LM, Mesitov MV, Moskovtsev AA. [Agonists of 5HT2C-receptors SCH 23390 and MK 212 incresase the force of rat aorta contraction in the presence of vasopressin and angiotensin II]. Patol Fiziol Eksp Ter. 2014 Oct-Dec;(4):17-29. Russian. PubMed PMID: 25980223.
Kuznetsova EG, Amstislavskaya TG, Bulygina VV, Tibeikina MA, Popova NK. Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice. Bull Exp Biol Med. 2006 Nov;142(5):594-7. PubMed PMID: 17415471.
de Mello Cruz AP, Pinheiro G, Alves SH, Ferreira G, Mendes M, Faria L, Macedo CE, Motta V, Landeira-Fernandez J. Behavioral effects of systemically administered MK-212 are prevented by ritanserin microinfusion into the basolateral amygdala of rats exposed to the elevated plus-maze. Psychopharmacology (Berl). 2005 Nov;182(3):345-54. Epub 2005 Oct 19. PubMed PMID: 16133141.
Halford JC, Lawton CL, Blundell JE. The 5-HT2 receptor agonist MK-212 reduces food intake and increases resting but prevents the behavioural satiety sequence. Pharmacol Biochem Behav. 1997 Jan;56(1):41-6. PubMed PMID: 8981607.

Other Notes

Small volumes of MK-212, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MK-212 purchase

MBS5756754 is an inhibitor targeting MK-212.

Additional Details

NCBI/Uniprot data below describe general gene information for MK-212. It may not necessarily be applicable to this product.

Protein Family

5-formyltetrahydrofolate cyclo-ligase-like protein

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.