Cyclopenthiazide Inhibitor

Cyclopenthiazide is a thiazide diuretic used to treat hypertension and heart failure. It decreases the excretion of calcium ions and uric acid and increases the excretion of sodium and potassium ions.

Krum H, Jackson B, Conway EL, Howes LG, Johnston CI, Louis WJ. Steady-state pharmacokinetics and pharmacodynamics of cilazapril in the presence and absence of cyclopenthiazide. J Cardiovasc Pharmacol. 1992 Sep;20(3):451-7. PubMed PMID: 1279292.
Passmore AP, Whitehead EM, Crawford V, McVeigh GE, Johnston GD. The antihypertensive and metabolic effects of low and conventional dose cyclopenthiazide in type II diabetics with hypertension. Q J Med. 1991 Nov;81(295):919-28. PubMed PMID: 1808632.
Johnston GD, Wilson R, McDermott BJ, McVeigh GE, Duffin D, Logan J. Low-dose cyclopenthiazide in the treatment,of hypertension: a one-year community-based study. Q J Med. 1991 Feb;78(286):135-43. PubMed PMID: 2031076.
Allman S, Norris RJ. An open, parallel group study comparing a frusemide/amiloride diuretic and a diuretic containing cyclopenthiazide with sustained release potassium in the treatment,of congestive cardiac failure--a multicentre general practice study. J Int Med Res. 1990;18 Suppl 2:17B-23B. PubMed PMID: 2193840.

Small volumes of Cyclopenthiazide, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5756755 is an inhibitor targeting Cyclopenthiazide.