Vacuolin-1 Inhibitor

Name: Vacuolin-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5756775
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5756775

Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin-1 is a potent and selective PIKfyve inhibitor and inhibits late-stage autophagy by impairing… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Vacuolin-1, Inhibitor

Full Product Name

Vacuolin-1

Form/Format

Solid. Powder

Purity/Purification

98.93%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

577.43

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C26H24IN7O

SMILES

Ic1cccc(\C=N\Nc2nc(nc(n2)N2CCOCC2)N(c2ccccc2)c2ccccc2)c1

CAS Number

351986-85-1

In Vitro

vacuolin-1 potently and reversibly inhibited the fusion between autophagosomes and lysosomes in mammalian cells, thereby inducing the accumulation of autophagosomes[1].

Product Categories/Family for Vacuolin-1, inhibitor

PI3K/Akt/mTOR signaling

Product References and Citations for Vacuolin-1, inhibitor

Yingying Lu, et al. Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A. Autophagy
Osamu Sano, et al. Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. FEBS Lett. 2016 Jun;590(11):1576-85.

Other Notes

Small volumes of Vacuolin-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Vacuolin-1 purchase

MBS5756775 is an inhibitor targeting Vacuolin-1.