INCB054329 Inhibitor

Name: INCB054329 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5756861
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5756861

INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2 with IC50 values of 44nM, 5nM, 9nM, 1nM, 28nM, 3nM, 119nM and 63nM… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

INCB054329, Inhibitor

Full Product Name

INCB054329

Product Gene Name

INCB054329, inhibitor

Product Synonym Names

INCB-054329,INCB-54329

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

348.36

Solubility

DMSO: 70mg/ml (200.94mM)
Ethanol: 70mg/ml (200.94mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C19H16N4O3

SMILES

CC1=C(C(=NO1)C)C2=CC=C3NC(=O)N4C(COC2=C34)C5=NC=CC=C5

CAS Number

1628607-64-6

Target & IC50

BRD2-BD2: ic50 5nM
BRD3-BD1: ic50 9nM
BRD3-BD2: ic50 1nM
BRD4-BD1: ic50 28nM
BRD4-BD2: ic50 3nM

Cell Research

Cell lines: DLBCL, AML, Myeloma cells. Incubation Time: 72 hours. Method: Cell viability assay

Product Categories/Family for INCB054329, inhibitor

Chromatin/Epigenetic; Epigenetic Reader Domain; Epigenetics

Product References and Citations for INCB054329, inhibitor

Stubbs MC, et al. Clin Cancer Res. 2019, 25(1):300-31
Phillip CC Liu, et al. AACR Cancer Res. 2015, 75(15 Suppl):Abstract nr 3523.
Wilson AJ, et al. Gynecol Oncol. 2018, 149(3):575-584.

Other Notes

Small volumes of INCB054329, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for INCB054329 purchase

MBS5756861 is an inhibitor targeting INCB054329.