• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

(+/-)-AMG487 Inhibitor – (+/-)-AMG 487

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5756981

AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36nM, respectively). More details

Please Inquire
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
(+/-)-AMG 487 ((+/-)-AMG487), Inhibitor
Full Product Name
(+/-)-AMG 487
Product Gene Name
(+/-)-AMG487, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
603.59
Solubility
DMSO: <60.36mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C32H28F3N5O4
SMILES
CCOC1=CC=C(N2C(C(N(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)CC4=CN=CC=C4)C)=NC5=C(C2=O)C=CC=N5)C=C1
In Vitro
AMG487 blocked in vitro lymphocyte migration mediated by CXCL9, CXCL10 or CXCL11. AMG487 did not affect the proliferation of 66.1 tumor cells at 24, 48 or 72 hours under normal or serum-free growth conditions. It did inhibit the migration of the tumor cells to CXCL9 by 70% [3].

Product Categories/Family for (+/-)-AMG487, inhibitor

Autophagy; GPCR/G Protein; Immunology/Inflammation

Other Notes

Small volumes of (+/-)-AMG487, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for (+/-)-AMG487 purchase

MBS5756981 is an inhibitor targeting (+/-)-AMG487. Also known as (+/-)-AMG 487.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000