Adenosine Kinase (hydrate) Inhibitor

Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations. Inhibition of adenosine kinase can selectively enhance the protective actions of adenosine during tissue trauma without producing the nonspecific effects associated with the systemic administration of adenosine receptor agonists (IC50: 1.7nM in cell-free assays).

Buang Y. Dietary adenine alleviates fatty liver induced by orotic acid. Indo. J. Chem. 2010; 10 (3): 363 - 369.
Buang Y. Dietary adenine alleviates fatty liver induced by orotic acid. Indo. J. Chem. 2010; 10 (3): 363 - 369.
Modis K, Ger D, Nagy N, Szoleczky P, Toth ZD and Szabo C. Cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis. Br J Pharmacol. 2009 Nov; 158(6): 1565-8.
Modis K, Ger D, Nagy N, Szoleczky P, Toth ZD and Szabo C. Cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis. Br J Pharmacol. 2009 Nov; 158(6): 1565-8.

Small volumes of Adenosine Kinase (hydrate), inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5757053 is an inhibitor targeting Adenosine Kinase (hydrate). Also known as Adenosine Kinase Inhibitor (hydrate).