Angiotensin Fragment (acetate) Inhibitor

Solid. Powder

98.00%

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

899

PBS: <=10mg/ml
(<1mg/ml refers to the product slightly soluble or insoluble)

C41H62N12O11-XC2H4O2

O=C([C@H](CC1=CNC=N1)NC([C@@]([H])(NC([C@H](CC2=CC=C(C=C2)O)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCNC(N)=N)=O)C(C)C)=O)=O)[C@H](CC)C)=O)N3CCC[C@H]3C(O)=O.CC(O)=O

The effects of chronic angiotensin fragment 1-7 treatment,was studied in an experimental model of the metabolic syndrome, rats given high-fructose/low-magnesium diet (HFrD). After 6 months, angiotensin fragment 1-7-treated animals had lower body weight, total fat mass, and serum triglycerides, improved glucose tolerance, and better insulin sensitivity. Similar metabolic effects were also evident, albeit in the absence of weight loss, in rats first exposed to HFrD for 5 months and then subjected to short-term treatment with angiotensin fragment 1-7 [2].