TASIN-1 Inhibitor

Name: TASIN-1 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5757117
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5757117

TASIN-1 is a small molecule inhibitor of mutant adenomatous polyposis coli (APC). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TASIN-1, Inhibitor

Full Product Name

TASIN-1

Product Gene Name

TASIN-1, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

352.49

Solubility

DMSO: >=35.2mg/mL
DMSO: >=35.2mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H28N2O3S

SMILES

CC1CCN(C2CCN(S(C3=CC=C(OC)C=C3)(=O)=O)CC2)CC1

CAS Number

792927-06-1

In Vitro

In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC [1].

Product Categories/Family for TASIN-1, inhibitor

Cell Cycle/Checkpoint

Product References and Citations for TASIN-1, inhibitor

Bai R L, Pettit G R, Hamel E. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. Journal of Biological Chemistry, 1990, 265(28): 17141-17149.
Bai R L, Pettit G R, Hamel E. Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites. Journal of Biological Chemistry, 1990, 265(28): 17141-17149.
Schwartsmann G. Marine organisms and other novel natural sources of new cancer drugs. Annals of Oncology, 2000, 11(suppl 3): 235-243.
Schwartsmann G. Marine organisms and other novel natural sources of new cancer drugs. Annals of Oncology, 2000, 11(suppl 3): 235-243.

Other Notes

Small volumes of TASIN-1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TASIN-1 purchase

MBS5757117 is an inhibitor targeting TASIN-1.