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CCT251545ue Inhibitor – Cct251545 Analogue, Compound 51

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5757118

CCT251545 analog is a potent and selective CDK8/19 inhibitor (IC50: 5.1nM and 5.6nM, respectively). Mediator complex-associated kinases CDK8 and CDK19 are involved in the regulation of multiple transcription pathways. CDK8 plays as an oncogene in gastric and… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCT251545 analogue, Compound 51 (CCT251545ue), Inhibitor
Full Product Name
CCT251545 analogue, Compound 51
Product Gene Name
CCT251545ue, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
414.46
Solubility
DMSO: >=20.7mg/mL with gentle warming
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C23H22N6O2
SMILES
NC1=C2C(N=C(C(N3CC(OC)C3)=O)C=C2)=C(C4=CC=C(C5=CN(C)N=C5)C=C4)C=N1
In Vitro
In vivo mouse and rat PK experiments, The compound demonstrated medium in vivo clearance and Vd but low bioavailability in mice. In an SW620 colorectal carcinoma human tumor xenograft model, Compound 51 (5mg/kg p.o. dose) inhibited phospho-STAT1SER727 in a time-dependent way. Compound 51 is an advanced chemical tool to further explore the efficacy, safety, and tolerability of dual CDK8/19 ligands [1].

Product Categories/Family for CCT251545ue, inhibitor

Cell Cycle/Checkpoint

Other Notes

Small volumes of CCT251545ue, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCT251545ue purchase

MBS5757118 is an inhibitor targeting CCT251545ue. Also known as CCT251545 analogue, Compound 51.
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