Dalfopristin (mesylate) Inhibitor

Dalfopristin (mesylate) is a streptogramin antibiotic and a 50S ribosome inhibitor. Streptogramins are produced by a variety of Streptomyces sp as a mixture (ratio of 7:3) of two chemically unrelated compounds, type A and B. Dalfopristin, the type A Streptogramin is often combined with type B streptogramin antibiotic, quinupristin, to produce Quinupristin-Dalfopristin Complex, known commercially as Synercid. The ribosome is composed of two ribonucleoprotein subunits, the 50S, and 30S. The 50S ribosome inhibitors inhibited protein synthesis.

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Gao M, Nettles R E, Belema M, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect[J]. Nature, 2010, 465(7294): 96-100.

Small volumes of Dalfopristin (mesylate), inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5757191 is an inhibitor targeting Dalfopristin (mesylate).