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NVP-BSK805 Inhibitor – 2hcl

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5757567

MBS5757567 is an inhibitor targeting NVP-BSK805. Also known as NVP-BSK805 2HCl. NVP-BSK805 2HCl is a potent and selective ATP-competitive inhibitor of JAK2. More details

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Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
NVP-BSK805 2HCl, Inhibitor
Full Product Name
NVP-BSK805 2HCl
Product Gene Name
NVP-BSK805, inhibitor
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
563.47
Solubility
DMSO: >=214mg/mL
Ethanol: >=8.03mg/mL with ultrasonic and warming
H2O: <1mg/mL
Ethanol: >=8.03mg/mL with ultrasonic and warmingmg
DMSO: >=214mg/mL
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C27H28F2N6O-2HCl
SMILES
C1CNCCC1N2C=C(C=N2)C3=NC4=C(C=CC=C4N=C3)C5=CC(=C(C(=C5)F)CN6CCOCC6)F.Cl.Cl
In Vitro
The oral bioavailability of NVP-BSK805 in mice was estimated to be 45%, while 50% in rats. In a Ba/F3 JAK2V617F cell-driven mouse model, Oral administration of NVP-BSK805 (150mg/kg) suppressed STAT5 phosphorylation, splenomegaly, and leukemic cell spreading. In BALB/c mice, NVP-BSK805 suppressedrhEpo-induced STAT5 phosphorylation as well as rhEpo-mediated polycythemia and splenomegaly at doses of 25, 50, and 100mg/kg orally [1].

Product Categories/Family for NVP-BSK805, inhibitor

Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells

Other Notes

Small volumes of NVP-BSK805, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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