Jolkinolide B Inhibitor

Name: Jolkinolide B Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758047
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758047

Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, through downregulation of JAK2/STAT3 and bcl-2, and upregulation of Bax and cytosolic cytochrome… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Jolkinolide B, Inhibitor

Full Product Name

Jolkinolide B

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

330.42

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Formula

C20H26O4

CAS Number

37905-08-1

Target & IC50

Akt
Bcl-2
Caspase
ERK
IL Receptor
JAK
JNK
mTOR
NF-kappaB
p38 MAPK
PI3K
STAT
TNF-alpha

Product Categories/Family for Jolkinolide B, inhibitor

Cytoskeletal Signaling; Akt; Angiogenesis; Chromatin/Epigenetic; Apoptosis; Proteases/Proteasome; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; MAPK; NF-kappab; PI3K/Akt/mTOR signaling

Product References and Citations for Jolkinolide B, inhibitor

Jolkinolide B inhibits RANKL-induced osteoclastogenesis by suppressing the activation NF-kappaB and MAPK signaling pathways. Biochem Biophys Res Commun. 2014 Mar 7;445(2):282-8.
Jolkinolide B from Euphorbia fischeriana Steud induces apoptosis in human leukemic U937 cells through PI3K/Akt and XIAP pathways. Mol Cells. 2011 Nov;32(5):451-7.

Other Notes

Small volumes of Jolkinolide B, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Jolkinolide B purchase

MBS5758047 is an inhibitor targeting Jolkinolide B.