Saikosaponin B1 Inhibitor

Saponin activator. Activates release of Prostaglandin E2 in vitro. Anti-inflammatory agent. Orally active. Active in vivo and in vitro.

Kyo R., et al. Antagonism of saikosaponin-induced prostaglandin E2 release by baicalein in C6 rat glioma cells. Biol Pharm Bull 22:1385-7 (1999).
Kida H., et al. Metabolism and pharmacokinetics of orally administered saikosaponin b1 in conventional, germ-free and Eubacterium sp. A-44-infected gnotobiote rats. Biol Pharm Bull 21:588-93 (1998).
Nishiyama T., et al. A distinct characteristic of the quiescent state of human dermal fibroblasts in contracted collagen gel as revealed by no response to epidermal growth factor alone, but a positive growth response to a combination of the growth factor and saikosaponin b1. Matrix 10:412-9 (1990).

Small volumes of Saikosaponin B1, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758094 is an inhibitor targeting Saikosaponin B1.