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Securinine Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758121

MBS5758121 is an inhibitor targeting Securinine. (-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist. More details

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Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Securinine, Inhibitor
Full Product Name
Securinine
Product Synonym Names
(-)-Securinine
Form/Format
Solid. Powder
Purity/Purification
99.58%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
217.26
Solubility
DMSO: 2mg/mL (9.21mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C13H15NO2
SMILES
O=C1O[C@](C2)([C@@H](CCCC3)N3[C@@H]2C=C2)C2=C1
CAS Number
5610-40-2
Target & IC50
GABAA
In Vitro
In the tumor model, tumor growth is significantly impaired with (-)-Securinine treatment,indicating that (-)-Securinine has potential as an Acute Myeloid Leukemia (AML) therapeutic. (-)-Securinine treated mice (n=5 mice, bilateral tumors), exhibit an average of more than 75% smaller tumors than vehicle-treated mice at the end of the study period.

Product Categories/Family for Securinine, inhibitor

Membrane transporter/Ion channel; GABA Receptor

Product References and Citations for Securinine, inhibitor

Stefanowicz-Hajduk J, et al. Securinine from Phyllanthus glaucus Induces Cell Cycle Arrest and Apoptosis in Human Cervical Cancer HeLa Cells. PLoS One. 2016 Oct 28;11(10):e0165372.
Stefanowicz-Hajduk J, et al. Securinine from Phyllanthus glaucus Induces Cell Cycle Arrest and Apoptosis in Human Cervical Cancer HeLa Cells. PLoS One. 2016 Oct 28;11(10):e0165372.
Kalpana Gupta, et al. Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML. PLoS One. 2011; 6(6): e21203.
Kalpana Gupta, et al. Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML. PLoS One. 2011; 6(6): e21203.

Other Notes

Small volumes of Securinine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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