9,13-Epidioxy-8(14)-abieten-18-oic acid Inhibitor

9,13beta-Epidioxy-8(14)-abieten-18-oic acid has anti-inflammatory activities, it exhibits moderate activities on NO levels in LPS-stimulated murine microglia BV2 cells, with IC50 values of 57.3 +/- 0.2uM. It is also a potential antitumor-promoting diterpenoid, it shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate. 9 alpha,13 beta -Epidioxyabeit-8(14)en-18-oic acid may contribute to the growth inhibitory effect of the pine needles and may play an important role in the allelopathy of red pine.

Diterpenes from the Trunk of Abies holophylla and Their Potential Neuroprotective and Anti-inflammatory Activities J. Nat. Prod., 2016, 79(2):387-94.
An allelopathic substance in red pine needles (Pinus densiflora). J Plant Physiol. 2009 Mar 1;166(4):442-6.

Small volumes of 9,13-Epidioxy-8(14)-abieten-18-oic acid, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758205 is an inhibitor targeting 9,13-Epidioxy-8(14)-abieten-18-oic acid.