A1874 Inhibitor

Name: A1874 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758227
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758227

A1874 is a nutlin-based and BRD4-degrading PROTAC which induces BRD4 degradation in cells. Effective in inhibiting many cancer cell lines proliferation. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

A1874, Inhibitor

Full Product Name

A1874

Product Gene Name

A1874, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

1173.59

Solubility

DMSO: 150mg/mL (127.81mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C58H62Cl3F2N9O7S

SMILES

COc1cc(C(=O)NCCOCCOCCOCCNC(=O)CC2N=C(c3ccc(Cl)cc3)c3c(sc(C)c3C)-n3c(C)nnc32)ccc1NC(=O)C1NC(CC(C)(C)C)C(C#N)(c2ccc(Cl)cc2F)C1c1cccc(Cl)c1F

CAS Number

2064292-12-0

Target & IC50

BRD4
BRD4
PROTAC

Product Categories/Family for A1874, inhibitor

Chromatin/Epigenetic; PROTAC

Product References and Citations for A1874, inhibitor

Hines J, et al. MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53. Cancer Res. 2019 Jan 1;79(1):251-262.
Hines J, Lartigue S, Dong H.et. Al.MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53[J].Cancer Res. 2019 Jan 1;79(1):251-262.

Other Notes

Small volumes of A1874, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for A1874 purchase

MBS5758227 is an inhibitor targeting A1874.