DORA-22 Inhibitor

DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory

Gamble M C, Katsuki F, Mccoy J G, et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model[J]. Sleep, 2019.
Gamble M C, Katsuki F, Mccoy J G, et al. The dual orexinergic receptor antagonist DORA-22 improves the sleep disruption and memory impairment produced by a rodent insomnia model[J]. Sleep, 2019.
Duncan M J, Farlow H, Tirumalaraju C, et al. Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice[J]. Alzhmer's & Dementia: Translational Research & Clinical Interventions, 2019, 5:70-80.
Duncan M J, Farlow H, Tirumalaraju C, et al. Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice[J]. Alzhmer's & Dementia: Translational Research & Clinical Interventions, 2019, 5:70-80.

Small volumes of DORA-22, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758231 is an inhibitor targeting DORA-22.