Columbianetin Inhibitor

Columbianetin is a new phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage, it also has antifungal activity. Columbianetin has anti-inflammatory effects, it promotes histamine release, and inhibits the histamine release by substance P, suggests that it may be helpful in regulating mast cell-mediated allergic inflammatory responses. (2'S)-columbianetin can be effectively used to protect keratinocytes from UVB induced damage.

Ahn B N, Kim J A, Kong C S, et al. Protective effect of (2'S)-columbianetin from Corydalis heterocarpa on UVB-induced keratinocyte damage[J]. Journal of Photochemistry & Photobiology B Biology, 2012, 109(none):20-27.
Ahn B N, Kim J A, Kong C S, et al. Protective effect of (2'S)-columbianetin from Corydalis heterocarpa on UVB-induced keratinocyte damage[J]. Journal of Photochemistry & Photobiology B Biology, 2012, 109(none):20-27.
Uzi, Afek, and, et al. Columbianetin, a phytoalexin associated with celery resistance to pathogens during storage[J]. Phytochemistry, 1995.
Uzi, Afek, and, et al. Columbianetin, a phytoalexin associated with celery resistance to pathogens during storage[J]. Phytochemistry, 1995.

Small volumes of Columbianetin, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758256 is an inhibitor targeting Columbianetin.