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CM-272 Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758291

MBS5758291 is an inhibitor targeting CM-272. CM-272 is a dual G9a/DNA methyltransferases (DNMTs) inhibitor. More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CM-272, Inhibitor
Full Product Name
CM-272
Product Gene Name
Form/Format
Solid. Powder
Purity/Purification
98.21%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
478.60
Solubility
DMSO: 96mg/mL (200.57mM)
Ethanol: 96mg/mL (200.57mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C28H38N4O3
SMILES
COc1cc2c(NC3CCN(C)CC3)cc(-c3ccc(C)o3)nc2cc1OCCCN1CCCC1
CAS Number
1846570-31-7
Target & IC50
G9a: ic50 8nM
GLP: ic50 2nM
DNMT1: ic50 382nM
DNMT3A: ic50 85nM
DNMT3B: ic50 1200nM (IC50)
Cell Research
Cell Line:CEMO-1, MV4-11 and OCI-Ly10 cell lines. Concentration:125nM, 250nM, 500nM (CEMO-1 cells); 135nM, 270nM, 540nM (MV4-11 cells); 100nM, 400nM, 1000nM (OCI-Ly10 cells). Incubation Time:12 hours, 24 hours, 48 hours and 72hours
In Vitro
CM-272, inhibits cell proliferation and promotes apoptosis, inducing interferon-stimulated genes and immunogenic cell deathours. CM-272 significantly prolongs survival of AML, ALL and DLBCL xenogeneic models.

Structure of CM-272, inhibitor

CM-272 Inhibitor – Cat# MBS5758291

Product References and Citations for CM-272, inhibitor

San Jose-Eneriz, Edurne, Agirre X, Rabal O, et al. Discovery of first-in-class reversible dual small molecule inhibitors against G9a and DNMTs in hematological malignancies[J]. Nature Communications, 2017, 8:15424.

Other Notes

Small volumes of CM-272, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CM-272. It may not necessarily be applicable to this product.

Protein Family

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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