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Imisopasem manganese Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758296

Imisopasem manganese (M40403) is a manganese superoxide MnSOD non-peptidyl mimetic. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Imisopasem manganese, Inhibitor
Full Product Name
Imisopasem manganese
Product Synonym Names
M40403
Form/Format
Solid. Powder
Purity/Purification
98.00%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
538.32
Solubility
DMSO: 31mg/mL (31.37mM)
Water: 15mg/mL (27.86mM) Need ultrasonic and warming
(<1mg/ml refers to the product slightly soluble or insoluble)
SMILES
[Cl-][Mn]1234([Cl-])([Mn+])[N]5=C6C=CC=C5C[NH]1[C@]7([H])CCCC[C@@]7([H])[NH]2CC[NH]3[C@@](CCCC8)([H])[C@]8([H])[NH]4C6
CAS Number
218791-21-0
In Vitro
M40403 has shown efficacy in animal model disease states in which superoxide anions are thought to play a key role. M40403 inhibits the inflammatory response following the intrapleural injection of carrageenan in rats. All parameters of inflammation are attenuated by M40403 except for NOx, PGE2 and IL-10 which remains unaltered [1]. Decreased apoptosis of the large and particularly the small bowel and marked recovery of both lymphoid and hematopoietic tissues occurs in the M40403 pre-treated mice [2].

Product References and Citations for Imisopasem manganese, inhibitor

Salvemini D, et al. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic,M40403. Br J Pharmacol. 2001 Feb;132(4):815-27.
Salvemini D, et al. Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic,M40403. Br J Pharmacol. 2001 Feb;132(4):815-27.
Masini E, et al. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol. 2002 Jul;136(6):905-17.
Masini E, et al. Protective effects of M40403, a selective superoxide dismutase mimetic, in myocardial ischaemia and reperfusion injury in vivo. Br J Pharmacol. 2002 Jul;136(6):905-17.

Other Notes

Small volumes of Imisopasem manganese, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Imisopasem manganese purchase

MBS5758296 is an inhibitor targeting Imisopasem manganese.
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