BAY-598 Inhibitor

MBS5758307 is an inhibitor targeting BAY-598. BAY-598 is a selective inhibitor of SMYD2 with IC50 values of 27nM.

Reynoird N, Mazur P K, Stellfeld T, et al. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer[J]. Genes & Development, 2016:genesdev;gad.275529.115v1.
Reynoird N, Mazur P K, Stellfeld T, et al. Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer[J]. Genes & Development, 2016:genesdev;gad.275529.115v1.
Eggert E, Hillig R C, K Hr S, et al. Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2[J]. Journal of Medicinal Chemistry, 2016:acs.jmedchem.5b01890.
Eggert E, Hillig R C, K Hr S, et al. Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2[J]. Journal of Medicinal Chemistry, 2016:acs.jmedchem.5b01890.

Small volumes of BAY-598, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.