TRH Inhibitor – Thyrotropin-Releasing Hormone

Name: TRH Inhibitor; Thyrotropin-Releasing Hormone; MyBioSource
Brand: MyBioSource
SKU: MBS5758310
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758310

Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) causes a variety of thyroidal and non-thyroidal effects, the best known being the feedback regulation of thyroid hormone levels. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Thyrotropin-Releasing Hormone (TRH), Inhibitor

Full Product Name

Thyrotropin-Releasing Hormone (TRH), Free Acid

Product Gene Name

TRH, inhibitor

Product Synonym Names

TRH-OH

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

363.37

Solubility

<1mg/ml refers to the product slightly soluble or insoluble

Boiling Point

896.0+/-65.0 degree C (Predicted)

Formula

C16H21N5O5

SMILES

O=C1CCC(C(=O)NC(Cc2c[nH]cn2)C(=O)N2CCCC2C(=O)O)N1

CAS Number

24769-58-2

Target & IC50

Others

In Vitro

Thyrotropin-releasing-hormone (TRH) stimulated the release of newly synthesized GH and PRL, but not thyroid-stimulating hormone. In addition, TRH stimulated a dose-related increase in the release of newly synthesized GH and PRL at 10(-9) to 10(-7) M. Cyclo(His-Pro) stimulated the release of newly synthesized GH dose- dependently. TRH, cyclo(His-Pro), and hGHRH stimulated GH synthesis, while SRIF inhibited this at 10(-7) M. The release of newly synthesized PRL into culture medium was also stimulated by TRH and hGHRH, but inhibited by SRIF. PRL synthesis was not affected by TRH-OH and cyclo(His-Pro). Intracellular contents of GH and PRL in the pituitary did not change significantly. TRH plays an important role in both GH and PRL synthesis and release[1].

Product References and Citations for TRH, inhibitor

Kagabu Y, Mishiba T, Okino T, et al. Effects of Thyrotropin-Releasing Hormone and Its Metabolites, Cyclo(His-Pro) and TRH-OH, on Growth Hormone and Prolactin Synthesis in Primary Cultured Pituitary Cells of the Common Carp,Cyprinus carpio[J]. General & Comparative Endocrinology, 1998, 111(3):395-403.
Kagabu Y, Mishiba T, Okino T, et al. Effects of Thyrotropin-Releasing Hormone and Its Metabolites, Cyclo(His-Pro) and TRH-OH, on Growth Hormone and Prolactin Synthesis in Primary Cultured Pituitary Cells of the Common Carp,Cyprinus carpio[J]. General & Comparative Endocrinology, 1998, 111(3):395-403.
Lopez-Barneo J, Castellano A, Toledo-Aral J. Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons.[J]. Proceedings of the National Academy of Sciences, 1990, 87(20):8150-8154.
Lopez-Barneo J, Castellano A, Toledo-Aral J. Thyrotropin-releasing-hormone (TRH) and its physiological metabolite TRH-OH inhibit Na+ channel activity in mammalian septal neurons.[J]. Proceedings of the National Academy of Sciences, 1990, 87(20):8150-8154.
Eleonore F, Richard W. The forgotten effects of thyrotropin-releasing hormone: metabolic functions and medical applications[J]. Frontiers in Neuroendocrinology, 2018:S0091302218300384-.
Eleonore F, Richard W. The forgotten effects of thyrotropin-releasing hormone: metabolic functions and medical applications[J]. Frontiers in Neuroendocrinology, 2018:S0091302218300384-.

Other Notes

Small volumes of TRH, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TRH purchase

MBS5758310 is an inhibitor targeting TRH. Also known as Thyrotropin-Releasing Hormone (TRH), Free Acid.

Additional Details

NCBI/Uniprot data below describe general gene information for TRH. It may not necessarily be applicable to this product.

Protein Family

Pro-thyrotropin-releasing hormone

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.