ARS-853 Inhibitor

ARS-853 is an inhibitor of K-RASG12C(IC50 : 2.5uM), a mutant form of K-RAS that accumulates in the active GTP-bound state in certain cancer cells

Lito P, Solomon M, Li L S, et al. Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism[J]. Science, 2016:science. Aad6204.
Lito P, Solomon M, Li L S, et al. Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism[J]. Science, 2016:science. Aad6204.
Patricelli M P, Janes M R, Li L S. Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.[J]. Cancer Discovery, 2016, 6(3):316.
Patricelli M P, Janes M R, Li L S. Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.[J]. Cancer Discovery, 2016, 6(3):316.

Small volumes of ARS-853, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758313 is an inhibitor targeting ARS-853.