NDI-091143 Inhibitor

Name: NDI-091143 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758321
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758321

NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1nM (ADP-Glo assay),indirectly disrupting citrate binding via an unexpected mechanism of inhibition. More details

Please Inquire

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NDI-091143, Inhibitor

Full Product Name

NDI-091143

Product Gene Name

NDI-091143, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

453.8

Solubility

DMSO: 91mg/mL (200.51mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C20H14ClF2NO5S

SMILES

COC(=O)c1cc(Cl)c(O)c(S(=O)(=O)Nc2cc(-c3ccccc3)c(F)cc2F)c1

CAS Number

2375840-87-0

Target & IC50

human ATP-citrate lyase: ic50 2.1nM
ACLY

Product Categories/Family for NDI-091143, inhibitor

Neuroscience; ATP Citrate Lyase; Metabolic Enzyme/Protease

Product References and Citations for NDI-091143, inhibitor

Jia, Wei, Silvana, et al. An allosteric mechanism for potent inhibition of human ATP-citrate lyase[J]. Nature, 2019.
Jia, Wei, Silvana, et al. An allosteric mechanism for potent inhibition of human ATP-citrate lyase[J]. Nature, 2019.
Granchi C.Discovery of Allosteric Inhibition of Human ATP-Citrate Lyase[J]. Trends Pharmacol Sci. 2019 Jun;40(6):364-366.
Granchi C.Discovery of Allosteric Inhibition of Human ATP-Citrate Lyase[J]. Trends Pharmacol Sci. 2019 Jun;40(6):364-366.

Other Notes

Small volumes of NDI-091143, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NDI-091143 purchase

MBS5758321 is an inhibitor targeting NDI-091143.