Adefovir Inhibitor

Name: Adefovir Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758343
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758343

Adefovir is an acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor used for treatment,of hepatitis B and herpes simplex virus infection. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Adefovir, Inhibitor

Full Product Name

Adefovir

Form/Format

Solid. Powder

Purity/Purification

100.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

273.19

Solubility

0.1 M NaOH: 10mg/mL (36.60mM) ultrasonic and adjust pH to 10 with NaOH
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C8H12N5O4P

SMILES

Nc1ncnc2c1ncn2CCOCP(=O)(O)O

CAS Number

106941-25-7

Target & IC50

Telomerase reverse transcriptase

In Vitro

adefovir is a potent inhibitor of DHBV replication that inhibits CCC DNA amplification but does not effectively prevent the formation of CCC DNA from incoming viral genomes[1].

Product Categories/Family for Adefovir, inhibitor

DNA Damage/DNA Repair; Telomerase

Product References and Citations for Adefovir, inhibitor

Delmas J, Schorr O, Jamard C, et al. Inhibitory Effect of Adefovir on Viral DNA Synthesis and Covalently Closed Circular DNA Formation in Duck Hepatitis B Virus-Infected Hepatocytes In Vivo and In Vitro[J]. Antimicrobial Agents and Chemotherapy, 2002, 46(2):425-433.
Delmas J, Schorr O, Jamard C, et al. Inhibitory Effect of Adefovir on Viral DNA Synthesis and Covalently Closed Circular DNA Formation in Duck Hepatitis B Virus-Infected Hepatocytes In Vivo and In Vitro[J]. Antimicrobial Agents and Chemotherapy, 2002, 46(2):425-433.
Park S, Kim W I, Cho D H, et al. Adefovir-induced Fanconi syndrome associated with osteomalacia[J]. Clinical and molecular hepatology, 2017, 24(3).
Park S, Kim W I, Cho D H, et al. Adefovir-induced Fanconi syndrome associated with osteomalacia[J]. Clinical and molecular hepatology, 2017, 24(3).
Leah A. Burke, et al. 155 - Drugs to Treat Viral Hepatitis. Infectious Diseases. Volume 2, 2017, Pages 1327-1332.

Other Notes

Small volumes of Adefovir, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Adefovir purchase

MBS5758343 is an inhibitor targeting Adefovir.