alpha-Cyano-4-hydroxycinnamic acid(alpha-CHCA) Inhibitor

alpha-Cyano-4-hydroxycinnamic acid (alpha-CHCA) is an inhibitor of monocarboxylate transporter 1 (MCT1) that blocks pyruvate transport in rat heart mitochondria (IC50 : 1.5uM).

Miranda-Goncalves V, Honavar M, Pinheiro C, et al. Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets[J]. Neuro-Oncology, 2013, 15(2):172-188.
Miranda-Goncalves V, Honavar M, Pinheiro C, et al. Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets[J]. Neuro-Oncology, 2013, 15(2):172-188.
Colen C B, Shen Y, Ghoddoussi F, et al. Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study[J]. Neoplasia, 2011, 13(7):620-632.
Colen C B, Shen Y, Ghoddoussi F, et al. Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study[J]. Neoplasia, 2011, 13(7):620-632.

Small volumes of alpha-Cyano-4-hydroxycinnamic acid(alpha-CHCA), inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758355 is an inhibitor targeting alpha-Cyano-4-hydroxycinnamic acid(alpha-CHCA).