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2,4-Diamino-6-hydroxypyrimidine Inhibitor

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758356

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis More details

Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
2,4-Diamino-6-hydroxypyrimidine, Inhibitor
Full Product Name
2,4-Diamino-6-hydroxypyrimidine
Product Synonym Names
DAHP
Form/Format
Solid. Powder
Purity/Purification
99.26%
Preparation and Storage
Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent
Molecular Weight
126.12
Solubility
DMSO: 25mg/mL (198.22mM)
(<1mg/ml refers to the product slightly soluble or insoluble)
Formula
C4H6N4O
SMILES
Nc1cc(=O)[nH]c(N)n1
CAS Number
56-06-4
Target & IC50
GTP cyclohydrolase I

Product References and Citations for 2,4-Diamino-6-hydroxypyrimidine, inhibitor

Sung Y J, Hotchkiss J H, Dieteri R R. 2,4-diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages[J]. International Journal of Immunopharmacology, 1994, 16(2):101-108.
Werner-Felmayer G, Werner E R, Fuchs D, et al. Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP[J]. Journal of Biological Chemistry, 1993, 268(3):1842-1846.

Other Notes

Small volumes of 2,4-Diamino-6-hydroxypyrimidine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

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MBS5758356 is an inhibitor targeting 2,4-Diamino-6-hydroxypyrimidine.
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