RS127445 Inhibitor – Rs 127445

RS 127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5).

Bonhaus D W, Flippin L A, Greenhouse R J, et al. RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist[J]. 1999, 127(5):1075-1082.
Bonhaus D W, Flippin L A, Greenhouse R J, et al. RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist[J]. 1999, 127(5):1075-1082.
Devroye, Celine, Haddjeri N, Cathala A, et al. Opposite control of mesocortical and mesoaccumbal dopamine pathways by serotonin 2B, receptor blockade: Involvement of medial prefrontal cortex serotonin 1A, receptors[J]. Neuropharmacology, 2017, 119:91-99.
Devroye, Celine, Haddjeri N, Cathala A, et al. Opposite control of mesocortical and mesoaccumbal dopamine pathways by serotonin 2B, receptor blockade: Involvement of medial prefrontal cortex serotonin 1A, receptors[J]. Neuropharmacology, 2017, 119:91-99.

Small volumes of RS127445, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS5758410 is an inhibitor targeting RS127445. Also known as RS 127445.