O6-Benzylguanine Inhibitor

Name: O6-Benzylguanine Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758427
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758427

O6-Benzylguanine is a guanine analog with antineoplastic activity, and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

O6-Benzylguanine, Inhibitor

Full Product Name

O6-Benzylguanine

Form/Format

Solid

Purity/Purification

98%

Preparation and Storage

Store at -20°C.

Molecular Weight

241.25

Solubility

DMSO: 48mg/mL (198.96mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C12H11N5O

CAS Number

19916-73-5

Target(IC50)

Apoptosis,DNA Alkylation,DNA/RNA Synthesis

HNMR

Consistent with structure

Conclusion

The product has been tested and meets the given quality standard.

Preparing Stock Solutions

1mM: 4.1451mL (1mg); 20.7254mL (5mg); 41.4508mL (10mg)
5mM: 0.829mL (1mg); 4.1451mL (5mg); 8.2902mL (10mg)
10mM: 0.4145mL(1mg); 2.0725mL (5mg); 4.1451mL (10mg)
50mM: 0.0829mL (1mg); 0.4145mL (5mg); 0.829mL (10mg)

Please select the appropriate solvent to prepare the stock solution, according to the solubility of the product in different solvents. Please use it as soon as possible.

Product Categories/Family for O6-Benzylguanine, inhibitor

DNA Damage/DNA Repair; DNA Alkylation

Product References and Citations for O6-Benzylguanine, inhibitor

Tacastacas J D, Chan D V, Carlson S. Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis FungoidesA Phase 1-2 Clinical Trial[J]. JAMA Dermatology, 2017, 153(5):pags. 413-420.
Tacastacas J D, Chan D V, Carlson S. Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis FungoidesA Phase 1-2 Clinical Trial[J]. JAMA Dermatology, 2017, 153(5):pags. 413-420.
Dolan M E, Pegg A E. O6-Benzylguanine and its role in chemotherapy[J]. Clinical Cancer Research, 1997, 3(6):837-847.
Dolan M E, Pegg A E. O6-Benzylguanine and its role in chemotherapy[J]. Clinical Cancer Research, 1997, 3(6):837-847.

Other Notes

Small volumes of O6-Benzylguanine, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for O6-Benzylguanine purchase

MBS5758427 is an inhibitor targeting O6-Benzylguanine.