CID-1067700 Inhibitor

Name: CID-1067700 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758446
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758446

CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases(Rab7 with a Ki of 13nM). More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CID-1067700, Inhibitor

Full Product Name

CID-1067700

Product Gene Name

CID-1067700, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

390.48

Solubility

DMSO: 68mg/mL (174mM) Need ultrasonic
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C18H18N2O4S2

SMILES

CC1(C)Cc2c(sc(NC(=S)NC(=O)c3ccccc3)c2C(=O)O)CO1

CAS Number

314042-01-8

Target & IC50

Rab7: ic50 13nM

In Vitro

CID-1067700 binds the nucleotide binding pocket of Rab7 with a Ki value of 13nM, preventing BODIPY-linked GTP and GDP binding with EC50 values of 11.2 and 21nM, respectively[1].

Product Categories/Family for CID-1067700, inhibitor

MAPK; Ras; GPCR/G Protein

Product References and Citations for CID-1067700, inhibitor

Agola J O, Hong L, Surviladze Z, et al. A Competitive Nucleotide Binding Inhibitor:, In Vitro, Characterization of Rab7 GTPase Inhibition[J]. ACS Chemical Biology, 2012, 7(6):1095-1108.
Agola J O, Hong L, Surviladze Z, et al. A Competitive Nucleotide Binding Inhibitor:, In Vitro, Characterization of Rab7 GTPase Inhibition[J]. ACS Chemical Biology, 2012, 7(6):1095-1108.
Yuan, Yang, Yong-ming, et al. CID 1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke[J]. ä¸-A›½è¯ç†A-¦æŠ¥:è‹+/-æ-‡ç‰ˆ, 2019(6):724-736.
Yuan, Yang, Yong-ming, et al. CID 1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke[J]. 2019(6):724-736.
Lam T, et al. Small Molecule Inhibition of Rab7 Impairs B Cell Class Switching and Plasma Cell Survival To Dampen the Autoantibody Response in Murine Lupus. J Immunol. 2016 Nov 15;197(10):3792-3805.

Other Notes

Small volumes of CID-1067700, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CID-1067700 purchase

MBS5758446 is an inhibitor targeting CID-1067700.