LM22A-4 Inhibitor

Name: LM22A-4 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758457
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758457

LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47nM in a fluorescence anisotropy assay) More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LM22A-4, Inhibitor

Full Product Name

LM22A-4

Product Gene Name

LM22A-4, inhibitor

Form/Format

Solid. Powder

Purity/Purification

98.00%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

339.34

Solubility

DMSO: 29mg/mL (85.46mM)
H2O: 50mg/mL (147.34mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C15H21N3O6

SMILES

O=C(NCCO)c1cc(C(=O)NCCO)cc(C(=O)NCCO)c1

CAS Number

37988-18-4

Target & IC50

TrkB: ic50 47nM
Trk

In Vitro

treatment of Het mice with LM22A-4 for 4 weeks rescued wild-type levels of TrkB phosphorylation in the medulla and pons and restored wild-type breathing frequency[1].

Product Categories/Family for LM22A-4, inhibitor

Tyrosine Kinase/Adaptors; Trk receptor

Product References and Citations for LM22A-4, inhibitor

Schmid D A, Yang T, Ogier M, et al. A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome[J]. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 2012, 32(5):1803-1810.
Schmid D A, Yang T, Ogier M, et al. A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome[J]. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 2012, 32(5):1803-1810.
Simmons D A, Belichenko N P, Yang T, et al. A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington"s Disease[J]. Journal of Neuroscience, 2013, 33(48):18712-18727.

Other Notes

Small volumes of LM22A-4, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LM22A-4 purchase

MBS5758457 is an inhibitor targeting LM22A-4.