TFLLR-NH2 Inhibitor – (2tfa)

MBS5758462 is an inhibitor targeting TFLLR-NH2. Also known as TFLLR-NH2 (2TFA). TFLLR-NH2(2TFA) is an agonist of PAR1 (EC50 :1.9 uM).

Kawabata A, Kuroda R, Kuroki N, et al. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle[J]. Life Sciences, 2000, 67(20):0-2530.
Kawabata A, Kuroda R, Kuroki N, et al. Characterization of the protease-activated receptor-1-mediated contraction and relaxation in the rat duodenal smooth muscle[J]. Life Sciences, 2000, 67(20):0-2530.
Jia Y, Zhang S, Miao L, et al. Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620[J]. Oncology Reports, 2015.
Jia Y, Zhang S, Miao L, et al. Activation of platelet protease-activated receptor-1 induces epithelial-mesenchymal transition and chemotaxis of colon cancer cell line SW620[J]. Oncology Reports, 2015.

Small volumes of TFLLR-NH2, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.