reverse T3 Inhibitor

Name: reverse T3 Inhibitor; MyBioSource
Brand: MyBioSource
SKU: MBS5758470
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS5758470

reverse T3 inhibits the increase of sodium current generated by other thyroid hormone analogs in neonatal rat myocytes. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

reverse T3, Inhibitor

Full Product Name

reverse T3

Product Synonym Names

3,3',5'-triiodo-L-thyronine

Form/Format

Solid. Powder

Purity/Purification

97.66%

Preparation and Storage

Store at -20 degree C for 3 years powder
-80 degree C for 2 years in solvent

Molecular Weight

650.97

Solubility

DMSO: 32.55mg/mL (50mM)
(<1mg/ml refers to the product slightly soluble or insoluble)

Formula

C15H12I3NO4

SMILES

N[C@@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O

CAS Number

5817-39-0

Target & IC50

Thyroid hormone

Cell Research

Brain death (BD) was induced in mechanically ventilated rats by inflation of a Fogarty catheter in the epidural space. T3 (0.1mg/kg) or vehicle was administered intraperitoneally 2 h prior to BD induction. After 4 h of BD, serum and liver tissue were collected. RT-qPCR, routine biochemistry, and immunohistochemistry were performed[1].

In Vitro

Reverse T3(T3) pre-conditioning leads to beneficial effects in the liver of brain-dead rats as seen by lower cellular injury and reduced apoptosis, and supports the suggested role of reverse T3(T3) hormone therapy in the management of brain-dead donors[1].

Product Categories/Family for reverse T3, inhibitor

Endocrinology/Hormones; Thyroid hormone receptor(THR)

Product References and Citations for reverse T3, inhibitor

Rebolledo R A, Erp A C V, Ottens P J, et al. Anti-Apoptotic Effects of 3,3',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats[J]. PLOS ONE, 2015, 10(4):249-250.
Rebolledo R A, Erp A C V, Ottens P J, et al. Anti-Apoptotic Effects of 3,3',5-Triiodo-L-Thyronine in the Liver of Brain-Dead Rats[J]. PLOS ONE, 2015, 10(4):249-250.
Nicod P, Burger A, Staeheli V, et al. Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results[J]. J Clin Endocrinol Metab, 1976, 42(5):823-829.
Nicod P, Burger A, Staeheli V, et al. Radioimmunoassay for 3,3',5'-triiodo-L-thyronine in unextracted serum: method and clinical results[J]. J Clin Endocrinol Metab, 1976, 42(5):823-829.

Other Notes

Small volumes of reverse T3, inhibitor vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for reverse T3 purchase

MBS5758470 is an inhibitor targeting reverse T3.